Testosterone Propionate has a specific androgenic effect: it stimulates the development and function of the external genitalia, prostate gland, seminal vesicles, as well as secondary sexual characteristics in men (voice, hairline). Participates in the formation of the body constitution and sexual behavior in men, increases libido and potency, stimulates spermatogenesis. Reduces the production of LH and FSH. Testosterone is an antagonist of female sex hormones – estrogens, has an antitumor effect on breast tumors in women. Has an anabolic effect, which is manifested by stimulation of protein synthesis, a decrease in fat deposition, a delay in the body of potassium, phosphorus and sulfur necessary for protein synthesis, an increase in calcium fixation in the bones and an increase in muscle mass. With sufficient protein nutrition, it stimulates the production of erythropoietin. Pharmacokinetics. After i/m or s/c administration, it is slowly absorbed from the injection site. Testosterone circulating in the blood enters the target organs, where it is reduced to 5-α-dihydrotestosterone, which interacts with cell membrane receptors and penetrates the cell nucleus. Up to 98% of the drug in plasma is bound to proteins, mainly globulins. It is metabolized in the liver to inactive and inactive metabolites, which are excreted from the body in the urine. Approximately 6% of the drug is excreted in the feces unchanged.
Indications Testosterone
Propionate replacement therapy for primary and secondary hypogonadism, eunuchoidism, impotence of endocrine origin, post-castration syndrome, male menopause, infertility due to impaired spermatogenesis, oligospermia, osteoporosis caused by androgen deficiency, breast cancer, menopausal disorders in women (in combination with estrogens), dysfunctional uterine bleeding with hyperestrogenism, mastopathy, accompanied by painful premenstrual tension of the mammary glands, endometriosis, uterine fibroids.
Pharmacodynamics
Androgenic agent, also has an anabolic effect. In target cells (skin, prostate, seminal vesicles, epididymis) it is reduced by 5-alpha-reductase to 5-alpha-dihydrotestosterone, which specifically interacts with cell surface receptors and penetrates into the nucleus. In some tissues (including the hypothalamus) it is converted to estradiol. In men it stimulates the development and activity of the gonads, prostate, seminal vesicles, the formation of secondary masculine characteristics (height, deep voice, beard and mustache growth), increases libido and potency; indirectly, through the central nervous system, it affects sexual behavior. Reduces fat deposition and excretion of trace elements. It suppresses the production and release of luteinizing hormone and follicle-stimulating hormone by the pituitary gland. Has anabolic effects: participates in the growth of the skeleton, increases the mass of skeletal muscles; causes the retention of nitrogen, phosphorus, potassium and sulfur ions necessary for protein synthesis.
